Introduction: Carney COMPLEX is an autosomal dominant syndrome that is defined with different tumors including myxoma in different organs, endocrine tumors and lentiginosis lesions. This is the first case report of this syndrome from Iran.Case: The patient is a 27 year old girl, referred with flank pain. Physical examination revealed hirsutism, truncal obesity, hyperpigmantasion and hypertension; Cushing's syndrome was suggested and confirmed with related classic biochemical tests. She had history of cardiac myxoma during her childhood and had been operated twice.Pituitary microadenoma and right adrenal adenoma were reported on MRI and CT-scan, respectively. Initially laparascopic right adrenalectomy was done; as expected, no remission in signs of Cushing's syndrome was observed after surgery. By laparoscopic adrenalectomy of the other site, Cushing's syndrome resolved. Pathologic report of 1st operation was adrenal adenoma with surrounding pigmented micronodular hyperplasia and of the 2nd one was just pigmented micronodular hyperplasia.Conclusion: We have reported a patient with Carney syndrome along with Cushing's syndrome due to bilateral adrenal hyperplasia and an adenoma in contralateral adrenal and microadenoma of the pituitary as an incidentaloma. This is a new presentation of Carney syndrome.

By introducing the second ligand 2,2’-bipy, a new copper (II) diphosphonate [Cu(H3L)(2,2′-bipy)] 1 (H5L=1-hydroxyethylidenediphosphonate, 2,2′-bipy=2,2′-bipyrimidine) has been hydrothermally synthesized and characterized by powder X-ray diffraction, elemental analysis, IR and TG-DTA. The single-crystal X-ray diffractions show that compound 1 possess a three-dimensional supramolecular structure, built from 1D chain via a single-bridge O–P–O in syn-anti fashion based on mononuclear unit [CuO3N2]. UV–vis spectra and the nature of electron transfer of 1 are investigated, and the experimental results are in agreement with the quantum chemistry calculation using the B3LYP/6-31G* method. Fluorescent measurements reveal that two emission peaks of 1 centered at 382.5 and 424.5 nm are mainly caused by intraligand p*–p emission state of the second ligands (375, 429.5 nm, l ex = 235 nm). Results of electrochemical studies (CV) indicate a higher donor ability of 1.

In this study, the solution chemistry and solid-state structures of a novel proton transfer compound, (pipzH2) (pyc)2·H2O 1, and three metal-organic COMPLEXes of [Mn (pyc)2(H2O)2]2·2H2O 2, [Ni(pyc)2(H2O)2]·H2O 3 and [Cu(pyc)2H2O]n 4, (pyc=pyridine-2-carboxylate, pipz=piperazine) were investigated. On the basis of crystallographic data, each MII ion is coordinated to pyridine-2-carboxylate as bidentate ligand. Furthermore, these COMPLEXes form a three-dimensional structure by a variety of noncovalent interactions such as extensive O-H···O, O-H···N, N-H···O, N-H···N, C-H···O hydrogen bonds, C-H···p and C-O···p interactions. The equilibrium constants for the binary pyc-pipz proton transfer system, the stoichiometry and stability of COMPLEXation of this system with Mn2+, Ni2+ and Cu2+ ions in aqueous solution were investigated by potentiometric pH titration method. In each case, the stoichiometry of the dominant metal COMPLEX species in solution was compared with that obtained from the crystal structure.

Introduction: Men with unexplained infertility and azoospermia are often observed in the context of genetic defects. The expression of a wide variety of genes is developmentally regulated  during human meiosis. Synaptonemal Protein 3 (SYCP3) gene, located on chromosome 12, encodes a DNA-binding protein as the structural component of the synaptonemal COMPLEX,which mediates the synopsis or homologous pairing of chromosomes during meiosis. Absence of SYCP3 in mice may lead to male infertility as well as female sub-fertility. SYCP3 expression analysis could be a tool for the prediction of human spermatogenesis progression, especially in infertile men.Materials & Methods: SYCP3 mRNA expression in testicular samples of 110 patients with non-obstructive azoospermia were studied in Avesina Infertility Clinic in Tehran, Iran during 2005 and early 2006. Semi-quantitative nested reverse transcriptase-PCR was employed in order to find the strength of gene expression. Using histopathological scoring for all samples, the expression level of SYCP3 during spermatogenesis was also evaluated.Results: Testicular SYCP3 mRNA expression was observed in 67 patients (60.9%). The expression level correlated with the degree of spermatogenic failure (p<0.0001). While this gene had been expressed in patients with hypo-spermatogenesis and maturation arrest, a lack of expression was seen in those with spermatogonial arrest, Sertoli cell-only syndrome and testicular atrophy.Conclusion: These data indicate that SYCP3 is expressed in the human testis and it is restricted to germ cells. Our findings, in association with those obtained in experimental animals, show that lack of SYCP3 expression may have negative effects on spermatogenesis and male fertility. SYCP3 gene expression may help detect specific spermatogenesis stages in conjunction with histopathological findings.

Two spotted spider mite (Tetranychus urticae COMPLEX) is an important pest of  egg-plant in Iran. In the present study, population of eggs and active stages and amount of losses of the spider mite were determined on upper and lower leaves of nine egg-plant cultivars in Varamin during 2001-2002. The experiment was in a randomized complete block design with three replications. Each plot consisted of four rows and on each row ten egg-plants were cultivated. Spider mite population on all cultivars was checked at weekly samplings, from July to October. Number of mites (eggs and active stages) on upper and lower leaves were then counted by stereo binocular microscope. Loss percent of mite was assessed by measuring the weight of ten randomly selected fruits of each cultivar in three replications at fifteen day intervals during fruiting period. Analysis of variance on data showed significant differences of mite population on upper and lower leaves of different cultivars and also among the cultivars. In 2000, the highest mean populations of active mites on lower leaves, 37.80 and 46.87, and on upper leaves, 27.19 and 38.08 were recorded on Borazjan cv. in naturally and artificially infested treatments, respectively. In 2001, egg and active mite populations on cultivar were significantly different only in artificially infested treatment. The maximum numbers of eggs (63.47) and active stage (107.94) were recorded on Imami 905 cultivar. Maximum and minimum losses of 69.42% and 12.86% were recorded on Imami 905 and Ghalami Varamin cultivars. These cultivars were determined as the most susceptible and resistant cultivars to mite damage, respectively.

In order to determine the fumonisin producing isolates of the Fusarium fujikuroi species COMPLEX (FFSC), associated with infected spikes, and ear rot of grass plants, we examined 78 samples collected from Kermanshah province, Iran. Based on morphological characters, twenty two isolates assigned to the FFSC and were identified as F. proliferatum (ten isolates), F. verticillioides (seven isolates), and F. subglutinans (five isolates). This was additionally approved using the specific primers of F. verticillioides, F. proliferatum, and F. subglutinans, i.e. VER1/VER2, PRO1/PRO2, and SUB1/SUB2, respectively. PCR–based detection of the fumonisin–producing isolates of FFSC was also achieved using the primers FUM1 F/FUM1 R. Out of twenty two isolates, eleven isolates (50%) determined as fumonisin chemotype.